3-氨基-4-甲氧基乙酰苯胺合成新工艺

New Synthetic Process of 3-Amino-4-Methoxy-Acetanilide

以 2 ,4-二硝基氯苯为原料 ,经甲醇醚化先制得 2 ,4-二硝基苯甲醚 ,再经 Raney镍催化氢化得 2 ,4-二氨基苯甲醚 ,不分离直接进行选择性酰化 ,合成出重要分散染料中间体 3-氨基 - 4-甲氧基乙酰苯胺 ,品质稳定 ,全程收率大于 80 %。

amino 4 methoxy acetanilide,an important intermediate for disperse azo dyes,has been prepared by selective acylation of 2,4 diaminoanisole ,which was synthesized by hydrogenation of 2,4 dinitroanisole catalyed by Raney Ni. 2,4, dinitroanisole was produced from 2,4 dinitrochlorobenzene.