血清脂蛋白(a)与Alzheimer病关系探讨

Relationship between the level of lipoprotein(a)and Alzheimer's disease

为探讨血清脂蛋白 (a) [L p(a) ]与 Alzheimer病 (AD)的关系。对 5 8例 AD患者和 16 0例健康人的血清血脂、载脂蛋白和 L p (a)进行检测。结果 :AD患者的 L p (a)水平 (中位数 )及异常率均明显高于对照组 (392 .38/ 15 6 .32 ,P<0 .0 1;46 .72 % / 2 0 .0 4% ,P<0 .0 1)。多元逐步回归分析显示 ,与甘油三酯 (TG)、低密度脂蛋白胆固醇 (L DL - C)相比 ,L P (a)与 AD之间有更显著的回归关系 (β=0 .2 8,P=0 .0 0 0 1,复相关系数为 0 .49)。提示高水平的 L P(a)是 AD的重要危险因素 ,检测血清 L p (a)对诊断

To study the relationship between concentration of lipoprotein(a)[LP(a)]and ALzheimer’s disease(AD)The concentration of Lp(a),apoA 1,apoB and blood-lipids were anlysed in 58 cases of Alzheimer’s disease and 110 cases of normal groupResults showed that the Lp(a) level and its abnormal rate of patient group were significantly higher than those of the normal group (39238/15632,P<001;4672%/2004%,P<001).Multivariate regression analysis revealed that the Lp(a) was a significant variable associated with AD compared with either TG or LDL-CIt suggest that the high level Lp(a) may play an important role in onset of AD and thus Lp(a) is a better predicting index for AD risk