LHRH离子电渗透皮给药系统的研究 II.离子电渗仪的研制和LHRH的大鼠药动学研究

Iontophoretic Transdermal Delivery of LHRH II. Development of Iontophoretic Device and Pharmacokinetic Study of LHRH Hydrogel Patch on Rats

设计了便携式离子电渗装置 ,采用石墨材料作电极 ,可以输出恒定的和不同频率、不同波形的脉冲直流电流 ,电渗时间和停药时间可以预先设置。研制了 L HRH的 PVA水凝胶贴片 ,进行了大鼠在体恒定和脉冲离子电渗透皮给药 ,结果表明离子电渗技术可以促进凝胶贴片中 L HRH的透皮转运 ,持续实验的 2 4h内 ,血清中可以维持平稳的 L HRH水平 ,从而诱导大鼠体内分泌的 L H水平有较明显的提高。通过电场的反转和中断可以模拟体内周期性的 L HRH分泌。

The improved iontophoretic device that is facile to handle has been developed with carbon electrodes. PVA hydrogel was formulated as vehicle for LHRH containing patch. In situ pharmacokinetic study of the patch on rats was carried out to investigate the serum LHRH and LH level under the continuous and pulse mode with the device.