诊断剂量的^(131)碘全身显像后甲状腺组织顿抑效应的评价

Evaluation of thyroid stunning after diagnostic whole body scanning with ^(131)I

目的 :探讨甲状腺癌切除术后诊断剂量 (185MBq)的13 1I全身显像是否会产生甲状腺组织顿抑效应而影响去除剂量的吸收。方法 :分化型甲状腺癌 87例 ,手术切除后给予13 1I(185MBq) 72h后进行诊断剂量的全身显像 ,显像结束后当天或隔天给予去除剂量的13 1I(370 0 - 740 0MBq)去除甲状腺组织。去除处理后第 5天再进行全身显像 ,并与诊断剂量的全身显像图比较 ,评价是否存在明显顿抑现象。结果 :甲状腺癌切除术后诊断剂量的13 1I全身显像并未产生明显顿抑现象 ,也未影响去除剂量的吸收 ,包括转移灶的数量和13 1I摄取的相对密度。结论 :13 1I去除治疗前 72h进行 185MBq的13 1I全身诊断性显像与甲状腺组织顿抑无关 。

Objective:To evaluate whether an 185MBq diagnostic dose of 131 I produces a visually apparent stunning effect 72h before 131I ablative therapy with post-thyroidectomy patients for differentiated thyroid carcinoma.Methods:87 cases with post-thyroidectomy patients for differentiated thyroid carcinoma received an 185MBq diagnostic dose of 131I followed by a whole-body diagnostic scan at 72h.The patients were admitted to the hospital and received a 131I ablative therapy dose of 3700-7400MBq.A post ablative whole-body scan was performed for any visual evidence of stunning.Results:No cases of visually apparent theyoid stunning were observed on any of the post ablative scans with regard to the number of 131I identified or the relative in density of 131I uptake seen.Conclusion:Diagnostic whole-body scanning can be performed effectively with an 185MBq dose of 131I 72h before radioiodine ablation without concern for thyroid stunning.