肺癌患者肺炎衣原体感染的研究

STUDY ON CHLAMYDIA PNEUMONIAE INFECTION IN PATIENTS WITH LUNG CANCER

目的 为了探索肺炎衣原体 (Cpn)和肺癌的关系。方法 应用聚合酶链反应 (PCR)和血清间接微量免疫荧光试验 (MIF)检测肺癌 80例 ,非肺癌基础肺病 80例痰中CpnDNA和血清中抗CpnIgM、IgG抗体。 结果 肺癌组Cpn急性感染率 (4 2 5 % )和慢性感染率 (86 % )均明显高于非肺癌肺病组 (8 8% ;71% ) ,肺癌合并Cpn急性感染者 ,除肺部罗音 ,胸片渗出性病变出现较高外 ,其他临床表现与无Cpn急性感染的肺癌无不同。结论 PCR是检测Cpn的有用方法 ,肺癌患者易患Cpn感染 ,Cpn感染与肺癌有一定的关系 。

Aim To investigate the relation between Chlamydia pneumoniae(Cpn) infection and lung cancer.Method Cpn in expectoration was detected by polymerase chain reaction(PCR) technique and the IgM and IgG antibody titers to Cpn in sera was detected by microimmunofluorescence antibody technique in 80 cases of lung cancer and in 80 cases of lung diseases without lung cancer.Results The rates of acute and chronic Cpn infections in lung cancer were higher than those of pulmonary disease patients without lung cancer.Except for dry or moist rales and effusion lesion in acute period.There was no difference in clinic features between the two groups.Conclusion PCR is a useful technique in Cpn detection.The lung cancer patients is liable to Cpn infection.Cpn infection may be associated with lung cancer.