冬虫夏草对未成年小鼠腹水型肝癌移植瘤生长影响的性别差异分析

ANALYSIS OF EFFECTS OF AWETO AGAINST PLANTED TUMOR OF LIVER CARCINOMA ASCITIC STRAIN ON JUVENILE MICE OF DIFFERENT SEXES

目的 :探讨具有雄激素样作用的冬虫夏草对肝癌细胞生长的影响。方法 :以不同性别未成年小鼠的腹水型肝癌皮下移植瘤为实验模型 ,从移植癌细胞当天起 ,每天给试验组小鼠经口灌服虫草水提物液体 2次 ,连续给药 3周 ,对照组不给药 ,满 1个月时终止实验 ,解剖小鼠 ,称瘤体湿重 ,比较对照组与试验组的平均瘤重和计算抑瘤率。结果 :在雌性小鼠中 ,呈现明显抑瘤效果 ,试验组平均瘤重明显小于对照组 ,抑癌率 :第一批为 33.0 0 71% ;第二批为 37.5 10 5 % ;第三批为 36 .0 0 99% ;在雄性小鼠中 ,则呈现相反作用 ,试验组平均瘤重明显大于对照组 ,促癌率 :第一批为 34.5 2 2 7% ;第二批为 31.2 388% ;第三批为 32 .8780 %。结论 :在与性激素相关的动物肿瘤中 ,冬虫夏草的抑癌或促癌活性可能受到性别差异的影响。在人体是否存在这种关系有待进一步研究。

Objective:To study the effects of aweto against liver carcinoma cell growth on juvenile mice of different sexes Methods:The experimental animal model was subcutaneously planted with tumor of liver carcinoma ascitic strain in juvenile mice These animals were divided into male group and female group Both were then divided into test subgroups and control subgroups respectively Every day,the mice of test groups were fed with aweto abstracts in water after the carcinoma cells were planted into mice All mice were dissected after four weeks The average tumor weight of the test and control groups was compared Meanwhile,the inhibited rate of tumor growth was counted Results:There were significant effects for inhibiting growth of tumor in female test groups mice The average tumor weight among female test groups is significantly lighter than control ones The inhibiting rates of tumor growth among three batches of animal experiments were 33 0072% for the first batch,37 5105% for the second batch and 35 1712% for the third batch Whereas,there were significant effects of promoting tumor growth on male test groups mice The average tumor weight of male test groups was significantly heavier than control ones The promoting rates of tumor growth among three batches of animal experiments were 34 5227% for the first batch,31 2388% for the second batch and 32 8780 for the third batch Conclusion:The effects of aweto in inhibiting or promoting tumor growth might be affected by sex difference of animals in some kinds of tumors which are related to sex hormone It can be expected in further research that there maybe this relation in human being