鼻咽癌高发家系成员EB病毒IgA/VCA抗体的对比研究

COMPARATINE RESEARCH OF EPSTEIN-BARR VIRUS IgA/VCA LEVEL AMONG MEMBERS OF MULTIPLE CASE NASOPHARYNGEAL CARINOMA FAMILES

目的 :探讨鼻咽癌高发家系的 EB病毒感染状况及其与遗传的相关性。方法 :用免疫酶法分别检测鼻咽癌高发家系成员 5 2 7人和自然人群 874人的 Ig A/ VCA抗体。结果 :高发家系成员中 ,Ig A/ VCA阳性率一级亲属为 2 9.2 8% ,二级亲属为18.75 % ,非血缘亲属为 8.11% ,均显著高于自然人群的 4.2 3% (P <0 .0 5 )。结论 :EB病毒感染也有家族聚集现象 ,鼻咽癌的发生可能是 EB病毒与遗传因素协同作用的结果。

Objective:This project was done in order to understand the Epstein Barr Virus (EBV) infective situation among multiple case nasopharyngeal carcinoma (NPC) families and the relationship between hereditary factor and EBV infection Methods:the immune enzyme assay was used for detecting serum IgA/VCA from 527 members of multiple case NPC families and 874 common population Results:the positive rate of EBV IgA/VCA is 29 28% in the first grade relations of NPC patients,18 75% in the second grade relations of NPC patients and 8 11% in the relations that there is not blood relationship to NPC patients They all are significantly higher than the common population 4 23%(P<0 05,respectively) Conclusion:The EBV infection has a gathering phenomenon in a family too NPC development may result from that genetic factor cooperates with the EBV infection