利培酮片的一阶导数分光光度测定

Determination of Risperidone Tablets by First Order Derivative Spectrophotometry

采用一阶导数分光光度法测定利培酮片的含量。以甲醇为溶剂 ,浓度在 5～ 40 μg/ml范围内 ,浓度 C与 2 5 4nm和 2 78.5 nm导数光谱峰谷间的振幅 D呈线性关系 ,r=0 .996 6。平均回收率为 99.91% ,RSD为 0 .0 5 %。

First order derivative UV spectrophotometry was applied for determination of risperidone tablets. It had good linearity between amplitude values ( D ) and concentrations ( C ) in 5~40 μg/ml in methanol solution, and the average recovery was 99.91% with RSD 0.05%.