缺血性心脑血管疾病患者血浆因子Ⅶ水平及临床意义

The serial measurements of coagulate factor Ⅶ and their clinical significance in patients with ischemic cerebral and heart diseases

目的 :系列测定缺血性心脑血管疾病患者血浆中凝血因子 (F )的水平并探讨其临床意义。方法 :冠心病 6 0例分为两组 :1血清胆固醇 (TC)与甘油三酯 (TG)正常组 30例 ;2血清 TC与 TG增高组 30例。缺血性脑卒中 40例 ,分别采用重组可溶性组织因子法测定活化因子 (F a) ,EL ISA法测定 F 抗原 (F Ag) ,一阶段凝固法测定 F 促凝活性 (F c) ,并计算 F a/ F Ag、F c/ F Ag的相对比值。结果 :冠心病血清 TC增高6 6 %与 TG增高 10 8%时 ,F a增加 16 % ,F c增加 14% (P <0 .0 5 )。缺血性脑卒中 F a(2 .7± 0 .9)μg/ L ,F c(97± 2 6 ) % ,与对照组相比 F a 与 F c 增高 (P<0 .0 5 )。结论 :F 为缺血性心脑血管疾病危险因子 ,系列测定F 水平为更有效的检测方法。

Objective:To measure the coagulate factor FⅦ in series and detect its clinical significance in patients with ischemic cerebral and heart disease.Method:Patients with coronary heart disease (n=60) were divided into 2 groups according to the serum level of cholesteral and triglycerin:Group Ⅰ (n=30) with normal values and GroupⅡ (n=30) with increased chlolesterol and triglycerin.Patients with ischemic cerebral stroke (n=40) also had a higher level of cholesteral and triglycerin.FⅦ a was detected by recombinant factor method.FⅦ Ag and FⅦ c were detected by ELISA and phase Ⅰ coagulation method, respectively, and the ratios of FⅦ a/FⅦ Ag and FⅦ c/FⅦ Ag were also made out.Result:In group Ⅱ, FⅦ a and FⅦ c increased by 16% and 14% when the value of cholesteral and triglycerin increased by 66% and 108%, respectively (P< 0.05 ).In patients with ischemic stroke, the value of FⅦ a was ( 2.7 ± 0.9 )μg/L, and FⅦ c was (97±26)%, and ratio of FⅦ a/FⅦ c was higher than that of control (P< 0.05 ).Conclusion:FⅦ is a risk factor for ischemic cerebral and heart diseases and serial measurement of FⅦ is a more effective method.