激素替代治疗后子宫内膜组织形态学与增殖细胞核抗原指数变化

Change between endometrial morphology and proliferating cell nuclear antigen index during hormone replacement therapy

目的 :探讨激素替代治疗后子宫内膜组织形态变化与增殖指标增殖细胞核抗原 ( PCNA)指数之间的关系。方法 :选择正常增殖期、分泌期、绝经后的子宫内膜及接受激素替代治疗 ( HRT)后的子宫内膜 ,根据病理诊断分为增殖期与分泌期 ,分别检测其中的PCNA水平。结果 :正常月经周期子宫内膜组织形态与 PCNA指数二者皆能反映子宫内膜的增殖与抑制状态。HRT后子宫内膜的形态 ,增殖期与分泌期与 PCNA指数所反映的内膜增殖与抑制状态有差异 ,PCNA水平与用药情况相符合。结论 :HRT后子宫内膜的增殖与抑制状态需要综合判断。

Objectives: To compare the endometrial morphology were proliferating cell nuclear antigen (PCNA) index after hormone replacement therapy(HRT). Design: Endometrium of the normal proliferative phase, secretory phase and postmenopause with or without HRT were chosen to observe the morphology and to detect the PCNA index. According to pathology diagnosis the endometrial samples were divided into two groups: proliferative and secretory phase. The level of PCNA was detected in both groups. Results: The endometrial morphology of normal menstrual cycle was coincidence with PCNA index in reflecting the endometrial proliferation and inhibition. However, after HRT the endometrial morphology changed in different way. The level of PCNA index was not in concert with the endometrial morphology. It was high even if in some secretory endometrium. Conclusion: This study suggests that the endometrial morphological changes were much different after the effect of estrogen and progestin. More markers should be used to evaluate the proliferation and inhibition of endometrium after HRT besides the endometrial morphology.