脑血管病脂蛋白(a)和其它脂类水平的研究

A Study on Levels of Lipoprotein(a) and Other Lipids in Patients with Cerebrovascular Diseases

目的探讨脑血管病患者脂蛋白 (a)〔L p(a)〕和其它脂类水平与脑血管病的关系。方法采用试剂盒检测5 5例脑出血 ,5 7例脑梗塞患者 L p(a)水平及胆固醇 (Ch)、甘油三酯 (TG)、高密度脂蛋白 (HDL )、载脂蛋白 A- I(Apo A- I)和载脂蛋白 B(Apo B) ,并与 85例健康对照者作比较。结果脑梗塞组 L p(a)、Apo B及 TG升高 ,HDL及Apo A- I下降 ;脑出血组 L p(a)、Apo B及 TG上升 ,Ch及 HDL下降明显。脑梗塞组 L p(a)与 TG呈显著正相关 ,而脑出血组 L p(a)与 Ch呈显著负相关。脑梗塞组 L p(a)、TG异常检出率分别高达 5 9.6 5 %、5 2 .6 3% ,脑出血组 HDL异常检出率高达 5 0 .91%。结论 L p(a)和其它脂类代谢异常是脑血管病患者最常见和重要的致病因素之一。

Objective To study the relationship between the changes of lipoprotein(a), other lipids and cerebrovascular diseases. Methods The serum levels of lipoprotein(a)〔Lp(a)〕apolipoprotein A I (Apo A I),apolipoprotein B(Apo B),cholesterol (Ch), triglyceride (TG) and high density lipoprotein cholesterol (HDL) were determined in 55 patients with cerebral infarction, 57 patients with cerebral hemorrhage and in 85 healthy controls by reagent kit. Results It was found that patients with cerebral infarction had significantly higher levels of Lp(a), Aop B and TG, and lower level of HDL.Patients with cerebral hemorrhage had significantly higher levels of Lp(a), Apo B, TG, and lower level of Ch than controls did. There was a significantly positive correlation between Lp(a) and TG in patients with cerebral infarction,while a significantly negative correlation between Lp(a) and Ch in patients with cerebral hemorrhage. The detective rates of abnormal Lp(a) and TG in cerebral infarction were as high as 59 65% and 52 63% respectively. The detective rate of abnormal HDL in cerebral hemorrhage was as high as 50 91%. Conclusion It is suggested that the abnormal Lp(a) and other lipids are one of the most common and important risk factors for cerebrovascular diseases.