饮食与前列腺癌危险性关系的病例对照研究

A Case-control Study on Diet and Risk of Prostate Cancer

目的评价不同食物的食用频度或习惯与前列腺癌危险性的关系。方法设计饮食频度问卷 ,采用以医院为基础的频数配比病例对照研究方法 ,对 149例经组织病理学或细胞学检查确诊的前列腺癌患者及按频数配比要求选配的 196例对照者的饮食情况进行调查 ;通过 SAS(6 .12 )软件对资料进行分析。结果单因素分析显示 :主食大米、牛奶、猪肉、禽肉、动物肝、蛋类、青绿菜及豆类食品与前列腺癌有统计学关联 (P<0 .0 5 ) ;多因素逐步非条件L ogistic回归分析结果显示 ,牛奶、猪肉、蛋类的食用习惯或频度与前列腺癌危险性增加有关 (P<0 .0 5 ) ;水果、青绿菜、豆类食品的食用频度则与前列腺癌危险性降低有关联 (P<0 .0 5 ) ;未发现鱼类、牛羊肉、喜食咸、喜食辛辣食物等食用频度或习惯与前列腺癌有关。结论牛奶、猪肉及蛋类等富含脂肪类食物是中国居民前列腺癌重要的危险因素 ;水果。

Objective To investigate the relationships between diet habits and the risk of prostate cancer.Methods A hospital based frequency matched case control study was conducted for a total number of 149 patients with prostate cancer and 196 matched controls.All the subjects were interviewed with an identical food frequency questionnaire.The data were analyzed with SAS version 6.12.Results Single factor analysis showed that there is statistical relation between rice,mile,pork,poultry,animal liver,eggs,green vegetables,bean products and prostate cancer ( P <0 05).Multivariate stepwise unconditional Logistic regression analysis results showed that the consumption frequency of milk,pork and eggs were independent risk factors for prostate cancer.The corresponding OR (95%CI) were 1.988(1.171～3.375),1.435(1.015～2.208) and 2.096 (1.535～2.863).The diet frequency of fruits,green vegetables and bean products were the independent protective factors for prostate cancer,and the corresponding OR (95% CI) were 0 567(0 361～0 891),0 478(0 304～0 753) and 0 370(0 265～0 516).No association was found between diet frequency of eating fishes,animal liver,beef or mutton,or habits of being fond of salty or pungent food and the risk of prostate cancer.Conclusion Milk,pork and eggs were the independent risk factors for prostate cancer,and fruits,green vegetables and bean products were the important protective factors for this cancer in Chinese.\;