结肠癌肝转移的介入性化疗栓塞术

Interventional chemoembolization for the liver metastases of colon carcinoma

目的 探讨介入化疗栓塞方法治疗结肠癌肝转移的疗效。方法 治疗组 40例采用介入法肝动脉栓塞化疗 ,对照组 30例采用常规全身静脉化疗。结果 介入化疗栓塞组有效率为 87.5 % (35 /4 0 ) ,全身静脉化疗组有效率为 36 .7% (11/30 ) ,两组有显著差异 (P <0 .0 1)。介入化疗栓塞组 40例中 6、12、2 4个月的生存率分别为 95 .4%、6 6 .7%、38.9% ,单纯静脉全身化疗组 30例中 6、12、2 4个月的生存率分别为5 9.7%、32 .3%、14.8%。结论 肝动脉化疗较全身静脉化疗疗效及生存期有明显提高。

Objective To study the therapeutic effects of chemoembolization for treatmen of liver metastases of colon carcinoma. Methods Hepatic arterial chemoembolization was performel in 40 cases (study group), and systemic chemotherapy was given in 30 cases (control group). Results The complete remission rate plus patial remission rato was 87.5%(35/40) in study group, and 36.7% (11/30) in control group. The difference between two groups was statistcally singnificant (P<0.01). For study group, the survival rate within 6, 12 and 24 months was 95.4%, 66.7% and 38.9%, respectively, while for control group was 59.7%, 32.3% and 14.8%. Conclusion The interventional hepatic arterial chemoembolization can improve the survival period and enhance the therapeutic effects in liver metastases of colon carcinomaw. compared with conventional systemic chemotherapy.