母乳喂养与乙型肝炎病毒传播的临床研究

Clinical Study on the Relationship between Breast Feeding and HBV Transmission

目的:探讨乙型肝炎病毒传播与母乳喂养的关系。方法:选择190例HBsAg阳性和120例HBsAg阴性母亲作临床研究。观察HBsAg阳性母亲不同喂养情况、其婴儿9个月时的HBsAg携带率及部分HBsAg阳性产妇乳汁中HBV-DNA和脐血中HBsAg情况。结果:在HBsAg阳性母亲中,其婴儿HBsAg携带率较HBsAg阴性母亲的婴儿高;母乳喂养组中,HBeAg阳性母亲其婴儿HBsAg阳性率较HBeAg阴性母亲者明显升高。结论:HBsAg阳性母亲中,血清HBeAg或乳汁HBV-DNA阳性者哺乳可能是导致婴儿感染乙型肝炎的一个危险因素。

Objective:To study the relationship between breast feeding and HBV transmission. Methods: 190 HBsAg positive mothers and 120 HBsAg negative mothers were studied. The HBsAg carrying rates of infants who were nine months were detected and analysed, according to the status of feeding in the HBsAg positive mothers. HBV-DNA of breast milk and HBsAg of cord blood were detected in the partial HBsAg positive puerpera. Results: The HBsAg positive rates of infants in the HBsAg positive mothers were higher than those of the HBsAg negative mothers. In the breast feeding group, the HBsAg positive rates of infants in the HBeAg positive mothers were higher than the HBeAg negative mothers. Conclusion: In the HBsAg positive mothers, HBeAg of blood or HBV-DNA of breast milk might play a possible risk factor in the HBV transmission.