肝胆舒康胶囊防治大鼠肝纤维化的实验研究

Experimental Study of Candan Shukang Capsules Against Immunodamaged Hepatic Fibrosis in Rats

目的:观察肝胆舒康胶囊对大鼠免疫性肝纤维化的防治效果。方法:分设肝胆舒康胶囊高、低剂量预防和治疗组以肝胆舒康灌胃。并与秋水仙碱对照,观察人血清白蛋白所致的免疫性肝纤维化大鼠的血清学、病理组织学及电镜指标的变化。结果:治疗组大鼠肝功能指标(血清白蛋白、总蛋白、ALT、AST)明显改善,肝纤维化血清学指标(HA、LN、PCⅢ)明显降低,肝组织胶原含量下降,肝组织纤维化程度明显减轻,电境下贮脂细胞数目及其胞浆细胞器明显减少,与实验空白对照组相比P<0.01,其综合疗效优于秋水仙碱。结论:肝胆舒康胶囊具有良好的防治肝纤维化的作用。

Objective: To study the blocking effects of traditional Chinese herbs Gandan Shukang capsules on im-munodamaged liver fibrosis in rats. Methods: Prevention and treatment group with various doses (including high and low doses) traditional Chinese Gandan Shukang capsules was given by stomach,contral group with colchicines. Serum procol-lagen type Ⅲ(PCⅢ), Hyaluronic acid (HA) and Laminin (LN) were detected, liver tissue was observed pathologically, number of fat-storing cell (FSC) and its organelles were examined. Results: Serum albumin, total protein, ALT, AST in the treatment group were remarkable improved. Serum PC Ⅲ, HA, LN were obviously lower. Gandan Shukang capsules could reduce the deposition of liver collagen. Liver fibrosis in treatment group was slight in compare with control group. FSC and its endoplasmic reticulum and mitochondria were inhibited. There was significant difference between the exemplar group and the treatment group (P<0. 01), the curative rate was better than colchicines. Conclusion: Gandan Shukang capsules is able to inhibit the deposition of collagen in the liver, so it is a useful anti-fibrotic drug in chronic liver diseases.