血栓通注射液治疗缺血性脑血管病的疗效观察

Observation on curative effects of Xueshuantong injection(血栓通注射液) on ischemic cerebrovascular disease

目的 :观察血栓通注射液治疗缺血性脑血管病的临床疗效。方法 :将 82例缺血性脑血管病患者随机分为治疗组 (4 0例 ) ,用血栓通注射液 5 0 0 m g加入 5 %葡萄糖 2 5 0 ml中静滴 ,每日 1次 ;对照组 (4 2例 )用复方丹参注射液 2 0 m l加入 5 %葡萄糖 2 5 0 ml中静滴 ,每日 1次 ;2组均以 2 0日为 1个疗程。治疗期间辅以抗生素、降颅压、降血压等治疗 ,均不使用其它扩血管药、抗凝药和溶栓药等治疗。结果 :治疗组平均显效时间 6日 ,总有效率 92 .5 % ,均明显高于对照组 (分别为 10日和 76 .2 % ,P均 <0 .0 5 )。2组患者血小板聚集、纤维蛋白原、全血粘度、血浆粘度均比治疗前明显降低 (P<0 .0 5或 P<0 .0 1) ,治疗组对上述指标的改善优于对照组 (P均 <0 .0 5 )。结论 :血栓通注射液治疗缺血性脑血管病的疗效显著 ,使用方便 。

Objective:To explore the efficacy of Xueshuantong injection(血栓通注射液) on treating ischemic cerebrovascular disease(ICVD).Methods:Eightytwo cases with ICVD were randomly divided into treatment group(n=40) which was treated with Xueshuantong injection 500 mg+5% glucose 250 ml infused intravenously once a day and control group(n=42),which was treated with composite salvia miltiorrhiza injection 20 ml+5% glucose 250 ml infused intravenously once a day.Twenty days were as one therapeutic course in both groups.In addition,any other vasodilator,anticoagulator,and thrombolytic drugs were not used but antibiotics,decreasing cranial pressure and hypotensive drugs were given.Results:The mean time of obvious improvement was 6 days,and total effective rate was 92.5% in treatment group,they were significantly higher than those in control group(10 days and 76.2% respectively,both P<0.05).On the other hand,blood viscosity,plasma viscosity,haematocrit and fibrinogen content were decreased after therapy in treatment group(P<0.05 or P<0.01).Conclusions:Xueshuantong injection possesses many merits in treating ICVD,including markedly curative effects,easy to use,no obviously poisoning and side effects.