摘要
观察了吸入0.004%的一氧化氮(NO)对急、慢性缺氧大鼠血流动力学、缺氧性肺血管收缩反应(HPV)、血气及高铁血红蛋白(MetHb)的影响。结果表明:(1)常氧吸入NO时能明显降低慢性缺氧大鼠肺动脉平均压(Ppa)和肺血管阻力(PVR),但对正常大鼠的Ppa和PVR无明显影响;(2)慢性缺氧大鼠急性缺氧时HPV较正常大鼠弱,吸入NO不但降低两者的急性缺氧肺动脉高压,且完全逆转两者的HPV;(3)吸入NO对急、慢性缺氧大鼠体循环血流动力学、血气及MetHb含量无明显影响。提示吸入NO能选择性降低急、慢性缺氧性肺动脉高压,且逆转HPV。
The effects of inhalation of 0.004% nitric oxide(NO)on hemodynamics,hypoxic pulmonaryvasoconstriction(HPV)blood gas and plasma methemoglobin(MetHb)level in acute as well aschronic hypoxic rats were investigated.The results were as follows:1.The mean pulmonary arte-rial pressure(P pa)and pulmonary vascular resistance(PVR)were signiflcantly decreased by in-haled NO in chronic hypoxic rats(P<0.01),but these changes were not observed in normoxiccontrol rats.2.The HPV was weaker in chronic hypoxic rats than that in control animals.Thepulmonary arterial hypertension induced by acute hypoxia was lowered greatly and HPVstrengthened by acute hypoxia was reversed completely by inhalation of NO in both chronichypoxic and control rats.3.There was no effect on systemic arterial pressure,systemic vascularresistance,PaO_2,PaCO_2 and MetHb level in acute and chronic hypoxic rats inhaling NO.It issuggested that the pulmonary arterial hypertension induced by acute and chronic hypoxia couldbe lowered selectively and the HPV induced by hypoxia could be reversed by inhalation of 0.004%NO in rats.
出处
《中国应用生理学杂志》
CAS
CSCD
1996年第2期140-143,共4页
Chinese Journal of Applied Physiology
基金
国家"八五"科技攻关课题
关键词
缺氧
一氧化氮
血流动力学
肺动脉高压
hypoxia,nitric oxide,hemodynamics
pulmonary hypertension