摘要
血管生成对原发性脑肿瘤和脑转移瘤的生长、转移起关键性作用。抗血管生成治疗通过对抗肿瘤血管生成 ,切断肿瘤的血供 ,从而遏制肿瘤的生长和转移 ,为难以控制的恶性脑肿瘤提供了一新的治疗策略。多种脑肿瘤 ,特别是原发恶性脑肿瘤是人体血管活性表达最强的肿瘤 ,是最理想的抗血管生成治疗对象。本文对脑肿瘤血管生成及抗血管生成治疗的研究进展做一综述。
出处
《国外医学（神经病学．神经外科学分册）》
2001年第2期135-138,共4页
Foreign Medical Sciences（Section On Neurology & Neurosurgery）
参考文献18
-
1Plate CH, Breier G, Weich HA, et al. Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors,distribution of VEGF protein and possible in vivo regulatory mechanisms. Int J Cancer, 1994,59:520-529
-
2Plate KH. Mechanisms of angiogenesis in the brain. J Neuropathol Exp Neurol, 1999,58:313 - 320
-
3Bren S, Tsanaclis AM, Gately S, et al. Immunolocalization of basic fibroblast growth factor to the microvasculature of human brain tumors.Cancer, 1992,70:2673 - 2680
-
4Morrison RS, Yamaguchi F, Bruner JM, et al. Fibroblast growth factor receptor gene expression and immunoreactivity are elevated in human glioblastoma mutiforme. Cancer Res, 1994,54:2794 - 2799
-
5Zagzag D, Friedlander DR, Miller DC, et al. Tenascin expression in astrocytomas correlates with angiogenesis. Cancer Res 1995;55:907-914
-
6Hayes A J, Li LY, Lippman ME. Science, medicine, and the futrre.Antivascular therapy: a new approach to cancer treatment. BMJ 1999,518:853 - 856
-
7O'Reilly MS, Boehm T, Shing Y, et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell, 1997,88:277 - 285
-
8Kirsch M, Strasser J, Allende R, et al. Angiostatin suppresses malignant glioma growth in vivo. Cancer Res, 1998,58:4654-4659
-
9TanakaT, Manome Y, Wen P, et al. Viral vector- mediated transduction of a modified platelet factor 4c DNA inhibits angiogenesis and tumor growth. Nat Med, 1997,3:437-442
-
10Lund EL, Spang Thomsen M, Skovgaard- Poulsen H, et al. Tumor angiogenesis-a new therapeutic target in gliomas. Acta Neurol Scand,1998,97:52-62
同被引文献40
-
1顾培元,胡卫星,傅震,吴幼章,潘士阳,丁小健.脑胶质细胞瘤患者手术前、后自然杀伤细胞（NK）活性测定及其临床意义[J].南京医科大学学报（自然科学版）,1995,15(3):577-579. 被引量：2
-
2朱诚 楼美清 等.脑胶质瘤的生物特性和治疗进展[J].中华神经外科杂志,2000,:24-26.
-
3Dannenbcrg AJ, Zakim D. Chcmoprevenfion of colorectal cancer through inhibition of cyelooxygenase - 2. Semin Oneol, 1999; 26(5) :499 - 504.
-
4Dempke W, Rie C, Grothey A. Cyelcoxygenase-2: a novel target for cancer chemotherapy? J Cancer Res Clin Oneol, 2001;127 (7):411--417.
-
5Joki T, Heese O, Nikas DC, et al. Expression of eyelooxygenase-2 in Human Glioma and in vitro inhibition by a specific Cox - 2 inhibitor, NS- 398. Cancer Res, 2000;60(17) :4926--4931.
-
6Shono T, Tofilon PJ, Bruner JM, et al. Cyelooxygenase - 2 expression in human gliomas: prognostic significance and molecular correlations. Cancer Res, 2001; 61(11): 4375--4381.
-
7Petersen C, Petersen S, Milas L, et al. Enhmeement of intrirksic tumor cell radiosensitivity induced by a selective eyelooxygenase - 2 inhibitor. Clin Cancer Res, 2000;6(6) :2513-2520.
-
8Kleihues P, Burger PC, Sdleithauer B.W. The new WHO classification of brain tumors. Brain Pathol, 1993; 3(3): 255--268.
-
9Weidner N. Cunrent pathologic methods for measuring intratumoral mierovessel density within breast carcinoma and other solid tumors.Breast Cancer Res Treat, 1995;36(2) : 169-- 180.
-
10Kaufmann WE, Andreasson KI, Isakson PT, et al. Cyclcoxygenase and the central nervous system. Prostaglandin' s, 1997; 54:601 --624.
引证文献3
-
1刘飞,廖达光,张天一,王知非,杨军.环氧合酶-2在人脑星形细胞瘤中的表达及其与微血管密度的关系[J].中国现代医学杂志,2003,13(11):27-29. 被引量：1
-
2孟年文.脑胶质细胞瘤治疗的研究进展[J].右江民族医学院学报,2004,26(1):112-114. 被引量：2
-
3刘泉开.脑胶质瘤的抗肿瘤血管生成治疗新进展[J].现代诊断与治疗,2004,15(3):129-131. 被引量：1
二级引证文献4
-
1朱浩,岳志健,周晓平.胶质瘤的抗血管生成治疗现状[J].中国微侵袭神经外科杂志,2008,13(6):281-283. 被引量：2
-
2于维东,范红杰,杨军,胡新华.环氧酶-2在大鼠局灶性脑缺血再灌注损伤中的表达及意义[J].中国现代医学杂志,2007,17(16):1934-1937. 被引量：2
-
3何瑜,刘继学,龚静国,刘金彩,曹宗申,李全喜,李广衡.闭合性腹部损伤后肝癌破裂出血2例[J].航空航天医学杂志,2013,24(10):1279-1280.
-
4刘志宏.机务人员颅内胶质母细胞瘤1例[J].航空航天医学杂志,2013,24(10):1280-1280.
-
1任旭艳,孔银香.肿瘤病人化疗的护理[J].中国社区医师（医学专业）,2009,11(23):240-241.
-
2叶玉斓,伊秀英,刘凤恩.血管瘤介入栓塞的护理体会(附1例报告)[J].赣南医学院学报,2007,27(1):140-140.
-
3王志良,常青,许莉,范魁生,吴孔明,周云.消癌平治疗原发性肝癌的临床疗效——根据生活质量(QOL)判定效果[J].工企医刊,1995,8(3):1-2.
-
4肺癌潜伏期可长达20余年[J].保健与生活,2014,0(12):36-36.
-
5李清朵,张燮良,张宝麟.原发性输卵管癌(附8例报告)[J].中国肿瘤临床,1989,16(6):343-345.
-
6刘景坡,关娟,安桂凤.27例宫颈癌术前新辅助化疗的疗效观察[J].中国肿瘤临床与康复,2010,17(1):62-63. 被引量：1
-
7宛敏浩,宋勇,夏锡荣.惠尔血治疗肿瘤化疗所致白细胞减少临床观察[J].安徽医学,1996,17(3):11-12.
-
8程亮,李媛,张绍渤,滕晓东.表皮生长因子受体信号途径和非小细胞肺癌个体化诊治进展[J].中华病理学杂志,2012,41(10):715-720. 被引量：3
-
9王秀娟.宫颈癌术前新辅助化疗的疗效探讨[J].中国医药导报,2008,5(5):46-47. 被引量：6
-
10陈军,陆建伟.甲基强的松龙联合格拉司琼治疗化疗引起的顽固性呕吐反应[J].河南肿瘤学杂志,2000,13(4):278-279.
