摘要
造血干 /祖细胞( HSC)移植是目前治疗多种恶性肿瘤及遗传性疾病的主要方法,而 HSC归巢骨髓的能力则决定了移植的成功与否。目前的研究证实,基质细胞衍生因子-1( SDF-1)及其受体( CXCR4)在 HSC增殖、分化及促进其归巢骨髓,重建造血功能中发挥着重要作用。本文就 SDF-1在造血调控中的作用及其机制作一综述。
Hematopoietic stem /progenitor cell transplantation is one of main choices for treating patients with malignant tumor or heredity diseases in recently year. The homing of hematopoietic stem cells(HSC) is a committed step to ensure the bone marrow hematopoiesis reconstitution. Recent studies have showed that stromal cell derived factor-1(SDF-1) and its receptor has important effects on proliferation, differentiation, homing of HSC to bone marrow and hematopoiesis reconstitution. The purpose of this review is to give a recent update informations on mechanism of hematopoiesis regulation mediated by SDF-1 and its receptor
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2001年第2期184-188,共5页
Acta Academiae Medicinae Sinicae