单甘酯对实验性血栓形成的影响

Effect of glycol mannate sulfate on experimental thrombosis

目的 研究单甘酯 (glycolmannatesulfate ,GMS)对血栓形成的影响。方法 结扎大鼠下腔静脉观察对静脉血栓的形成 ,Chandler方法观察体外血栓形成 ,全自动凝血仪测定凝血指标和纤维蛋白原及ATⅢ、Ⅱ、Ⅱa活性。结果 GMS 2 0、40mg·kg-1对大鼠静脉血栓的形成有抑制作用 (P<0 0 1) ;2 5mg·kg-1即能明显抑制家兔体外血栓的形成 ,随剂量的增加而增强。GMS可使家兔TT、CT、APTT、RT及PT明显延长 ,降低大鼠血浆纤维蛋白原含量及降低因子Ⅱ及因子Ⅱa活性 ,升高ATⅢ活性。结论 GMS具有明显的抗血栓形成作用 。

AIM To investigate the antithrobosis effects of glycol mannate sulfate(GMS). METHODS Vein thrombus was formed in rat by ligating postcava. Thrombus formation in vitro was observed by Chandlers method. Clotting indexes were measure by ACL200 congulation system. RESULTS GMS dosage of 20、40 mg·kg -1 could inhibit the vein thrombus formation in rats ( P <0 01). GMS could inhibit the thrombosis in rabbit, in vivo , and the inhibitory action was enhanced along with the increase of dosage. The CT,TT,CT,APTT,RT and PT were prolonged, and the fibrinogen and the activity of Ⅱ and Ⅱa were decreased. The activity of ATⅢ was enhenced. CONCLUSION GMS has antithrombotic effect and the mechanism may be related to the anticongulat effect.