摘要
使用D 半乳糖造成小鼠实验性衰老模型 ,观察肉苁蓉多糖对实验性衰老小鼠肺胶原蛋白、弹性蛋白含量的影响 ,对肺组织和红细胞中超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH Px)及丙二醛 (MDA)含量的影响。结果 灌服肉苁蓉多糖的衰老小鼠的肺组织及红细胞中SOD、GSH Px活力不同程度提高 ,肺及血浆中丙二醛含量有所降低。同时肺胶原蛋白含量减少 ,弹性蛋白含量增多。
AIM The relation between lung collagen,lung elastin and anti oxidative capacity was investigated in the experiment, and the aging model of mice was induced by D galactose. METHOD The aging mice treated with cistanche desertica polysacchrides (50,100 mg·kg -1 ·d -1 ) and determinate the modification of SOD、GSH Px、Vit E、MDA in blood and lung. RESULTS Cistanche desertica polysacchrides (CDP), which was isolated from Cistanche desertica cultivated in Xinjiang could enhance lung anti oxidative capacity and inhibit the modification of lung elatic constitution induced by D galactose. CONCLUSION Cistanche desertica polysacchrides have anti oxidative injury and anti aging effects on lung.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2001年第1期101-103,共3页
Chinese Pharmacological Bulletin
关键词
衰老
肺胶原蛋白
弹性蛋白
抗氧化功能
肉苁蓉多糖
抗衰老
ageing
lung collagen
lung elastin
anti oxidative capacity
cistanche desertica polysacchrides