胎儿宫内生长迟缓的实验动物模型

The experimental animal models of intrauterine growth retardation

目的 建立胎儿宫内生长迟缓的实验动物模型及观测指标。方法 妊娠动物被动吸烟、被动吸烟 +饮酒、注射亚硝基左旋精氨酸甲酯、注射更生霉素、维生素B1缺乏饮食+抗硫胺素、结扎子宫动脉等。结果 胎仔体重降低、身长短小 ,幼仔体格及神经系统发育缓慢 ,母体体重降低、血液营养物质和胎盘血流减少 ,胎盘组织细胞结构和功能发等。

AIM This paper was to review the methods of establishing experimental animal models of intrauterine growth retardation (IUGR) and their observed index. METHODS Passive smoking, passive smoking plus drinking wine, N G nitro L arginine methyl ester, dactinomycin, thiamine deficiency plus pyrithiamine, or ligating the uterine artery during pregnancy were used.RESULT The fatal and maternal body weight was lower body length; was shorter; infant physique and nerve system development was slow.CONCLUSION The above methods could establish animal models of IUGR.