硝酸结合MNNG攻击大鼠胃癌模型与评价

A new animal model of gastric cancer induced by MNNG's attacking combining ulcer

目的 建立一种诱癌率高、实验周期较短且更接近于临床胃癌发病的胃癌动物模型。方法 采用醋酸致溃疡结合MNNG攻击的多因素法诱发大鼠胃癌 ,以大鼠腺胃组织病理切片结果判定胃癌诱发情况。结果 所检模型组 15型大鼠有 6例为腺胃癌或重度非典型增生 ,但未发现肿那个 ,4例萎缩性胃炎 ,2例轻度异型增生 ,2例浅表性胃炎 ,胃癌发生率达 40 %。结论 该方法所诱发大鼠胃癌模型周期短 ,癌发率较高 。

AIM To establish a new animal model of gastric cancer with high incidence rate and short experimental period. METHODS Using N methyl N′ nitro N nitrasoguanidine(MNNG) combining ucler to induce rats to gastric cancer, taking the pathological situation of rats as the standard of canceration. RESULTS Six rats coming from model group were found as gastric cacinoma, the incidence rate of gastric cancer can reach forty percent. CONCLUSION This method can induce high incidence rate of gastric cancer during short experimental period. It deserves imroving and developing.