心康口服液对实验性小鼠柯萨奇B_3病毒性心肌炎的实验研究

Experimental Study on Effect of Xinkang Oral Liquid on Coxsackie B_3 Viral Myocarditis in Mice

目的 :观察心康口服液治疗小鼠柯萨奇B3(CVB3)病毒性心肌炎的疗效。方法 :将小鼠随机等分为模型组、阳性药对照 (Ribavilin)组、心康口服液组及正常对照组 ,并腹腔接种CVB3病毒液建立病毒性心肌炎模型。观察比较 4组小鼠 5、10、2 0天体重、心脏重量、心脏肉眼及组织形态学改变 ,同时进行形态定量学检查及统计学分析。结果 :心康口服液组小鼠体重增加 ,心肌坏死程度轻 ,范围小 ,组织修复完全。结论 :心康口服液对病毒性心肌炎小鼠有一定疗效 ,该药保护心肌及抗病毒作用优于Ribavilin。

Objective: To study the therapeutic effect of Xinkang Oral Liquid (XKOL) in treating acute Coxsackie B 3 viral myocarditis in mice. Methods: Viral myocarditis model was established by intraperitoneal inoculation with Coxsackie B 3 virus. Mice were randomly divided into 4 groups randomly, the model group, the positive control group (treated with Ribavilin), the XKOL group and the normal control group. Body weight of mice was weighed at the 5th, 10th and 20th day. Weight, macro and histopathologic changes of heart were observed by microscope and measured by morphometric quantification, and the data were treated statistically. Results: In the XKOL group, the body weight of mice increased, the degree of myocardial necrosis mild and small in size, which has been repaired more completely, the antiviral effect was found in XKOL group. Conclusion: XKOL has definite therapeutic effect on viral myocarditis, its effect is better than Ribavilin in protecting myocardium and anti virus.