H受体阻滞剂对手术并急性肺损伤的干预作用

The intervening effect of H-recepter blocking agent on operation and acute lung injury

目的：了解Ｈ受体阻滞剂在手术并发急性防损伤（ＡＬＩ）中的作用。方法：腹部手术中采用油酸静脉注射造成急性肺损伤，观察盐酸异丙嗪（Ｈ１受体阻滞剂）和百米替丁（Ｈ２受体阻滞剂）对损伤肺嗜中性粒细胞聚集及对氧自由基水平的影响。结果：两者均能有效地抑制嗜中性粒细胞在防内的聚集，对氧自由基的产生有一定抑制作用，西米替丁的作用更为明显。结论：Ｈ受体阻滞剂特别是Ｈ２受体阻滞剂可作为术中及术后预防和治疗急性肺损伤的药物。

Objective To study the effect of H-recepter blocking agent in operation and ALI. Method In abdomen operation with ALI caused by intravenous injection of oleic acid, the influence of promethazine hydrochloride and cimetidini on the aggregation of neu- trophilic granulocytes of injured lungs and oxygen freeradical level were observed. Results Both of them can effectively inhibit the aggregation of neutrophilic granulocytes and had some inhibiting effect on free-radical of oxygen, especially cimetidini. Conclusion H-re- cepter blocking agent, especially H2 recepter blocking agent can be used during or after operation to prevent and treat ALI.