摘要
目的 为探索慢性骨髓炎并大段炎性骨段的早期外科治疗和术后大段骨缺损一期修复的可行性治疗。方法观察抗生素经介入后的体内药物代谢的情况。方法 按不同时间段 ,将 36只青紫兰兔随机等分为 6组。每组 6只再编号随机分为两小组 ,用胫骨干骺端髓腔开窗 2 0cm× 0 2cm并放置棉球复制出具有大段炎性骨段的慢性骨髓炎动物模型 ,一组接受抗生素的介入 ,一组用静脉滴注治疗为对照组 ,于用药后 0 5h、 1h、 2h、 3h、 6h和 12h采用微生物法的琼脂扩散单层法测定动物血液、病灶周围软组织和病灶炎性骨段的抗生素药物浓度。结果 在不同时间段内 ,组织中介入治疗组的抗生素含量比静脉推注组的高 ,其中在术后 0 5h、 1h和 2h (P <0 0 1) ,术后 3h和 6h (P <0 0 5 ) ;炎性组织在术后 0 5h、 2h和 2h (P <0 0 1) ,术后 3h和 6h (P <0 0 5 )。血液中则相反 (P <0 0 5 )。介入治疗组炎性骨的抗生素含量和正常骨的差与静脉推注组的二者之差有显著差别 (P <0 0 1)。结论 术前 3h内经感染灶动脉插管给予抗生素青霉素G介入治疗 ,能保证慢性骨髓炎清除术术野有足够的抗菌能力。
Objective To study the early therapy method of chronic osteomyelitis with a large infected bone and one stage reconstruct the postoperative segmental defect of bone by decreasing antibiotic in the body after interventional therapy Methods According to the different time 36 rabbits were randomly divided into 6 groups Then each group was divided into two groups again, with 2 cm×0 2 cm size of opening window in the tibia Then the cotton globule were placed and the model of chronic osteomyelitis were made The interventional therapy was involved in one group, the therapy of injection in vein was contrasted in another group Then, according to the different times (0 5 h,1 h,2 h,3 h,6 h and 12 h) to determine the level of antibiotic in bone, tissue and serum by using the methods of microassay in the standard agar diffusion Results The level of antibiotic in the tissue in the group with interventional therapy was higher than that of the tissue in contrast, especially in postoperative 0 5 h , 1 h and 2 h (P<0 01) The level of antibiotic in the diseased bone was higher than that of in the normal bone (P<0 05) Conclusion Within 3 hours after injected antibiotic by intervential therapy in the treatment of surgery of chronic osteomyelitis is better than the conventional method There is higher antibiotic concentration in the area of operation for chronic osteomyelitis than that of injection in vein
出处
《骨与关节损伤杂志》
2001年第2期111-114,共4页
The Journal of Bone and Joint Injury
