结直肠癌基因治疗研究进展被引量：23

Progress in the studies of gene therapy for colorectal cancer

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摘要结直肠癌是常见的消化道恶性肿瘤,其治疗以手术治疗为主,同时辅以放化疗,但术后5年生存率在50%左右,约半数的患者5 a后出现复发或转移.对失去手术机会或转移性患者主要采取以5-FU为主的化疗和生物治疗.肿瘤基因治疗是生物治疗的发展和新支柱,是肿瘤生物治疗的里程碑.它是将含目的基因的重组DNA或RNA转移到受体细胞内,使之在细胞内表达,以诱发免疫应答反应,控制和调节机体抗癌功能.本文就结直肠癌基因治疗现状予以综述.

作者范应方黄宗海

机构地区中国人民解放军第一军医大学珠江医院普外科

出处《世界华人消化杂志》 CAS 2001年第4期427-430,共4页 World Chinese Journal of Digestology

关键词结肠直肠肿瘤治疗基因疗法

分类号 R735.3 [医药卫生—肿瘤]

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共引文献203

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同被引文献261

1唐德生,张建国,周东航,李伟安,师恩惠.结直肠癌术后早期5～FU大剂量大容积腹腔灌注化疗的临床应用[J].世界华人消化杂志,2000,8(z1). 被引量：2
2Wen Jie Dai,Hong Chi Jiang Second Department of General Surgery, the First Clinical School, Harbin Medical University, Harbin 150001, Heilongjiang Province, China.Advances in gene therapy of liver cirrhosis: a review[J].World Journal of Gastroenterology,2001,7(1):1-8. 被引量：34
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4Xing Wang Wang~1 Jin Hui Yuan~1 Ru Gang Zhang~1 Li Xia Guo~1 Yong Xie~2 Hong Xie~1 ~1Department of Biotherapy,Shanghai Institute of Cell Biology,Chinese Academy of Sciences,Shanghai 200031,China ~2Department of Biology,Hong Kong University of Science and Technology,ChinaDr.Xing Wang Wang earned Ph.D.from Shanghai Institute of Materia Medical,Chinese Academy of Sciences in 1997.Now a professor at Shanghai Institute of Cell Biology,Chinese Academy of Sciences..Antihepatoma effect of alpha-fetoprotein antisense phosphorothioate oligodeoxyribonucleotides in vitro and in mice[J].World Journal of Gastroenterology,2001,7(3):345-351. 被引量：21
5Ping Yuan~1 Meng Hong Sun~2 Jin Sheng Zhang~1 Xiong Zeng Zhu~2 Da Ren Shi~2 ~1Department of Pathology,Medical College of Fudan University,~2Department of Pathology,Cancer Hospital/Cancer Institute,Fudan University,Shanghai 200032,ChinaDr.Ping Yuan Studying Province.studying in Medical College of Fudan University,worked in Department of Pathology,Wannan Medical College,having eighteen papers published..APC and K-ras gene mutation in aberrant crypt foci of human colon[J].World Journal of Gastroenterology,2001,7(3):352-356. 被引量：20
6Qing He Nie Yong Qian Cheng Yu Mei Xie Yong Xing Zhou Yi Zhan Cao The Center of Infectious Disease Diagnosis and Treatment of PLA,Tangdu Hospital,Forth Military Medical University,Xi’an 710038,Shaanxi Province,ChinaDr,Qing He Nie graduated from Qinghai Medical College as a doctor in 1983,got master degree at Beijing 302 Army Hospital in 1993,got doctor degree at the Third Military Medical University in 1998,engaged in postdoctoral research at the Fourth Military Medical University from 1998 to 2000,now an associate professor,specialized in clinical and experimental research of infectious diseases,had more than 90 papers published,coauthor of ten books,first author of one book..Inhibiting effect of antisense oligonucleotides phosphorthioate on gene expression of TIMP-1 in rat liver fibrosis[J].World Journal of Gastroenterology,2001,7(3):363-369. 被引量：73
7Zhao-You Tang Liver Cancer Institute & Zhongshan Hospital of Fudan University Professor of Surgery Chairman.Liver Cancer Institute of Fudan University(previous Liver Cancer Institute of Shanghai Medical University)136 Yixueyuan Road,Zhongshan Hospital,Shanghai 200032,China..Hepatocellular Carcinoma-Cause,Treatment and Metastasis[J].World Journal of Gastroenterology,2001,7(4):445-454. 被引量：213
8Ming-Yao Wu Mao-Huai Chen Ying-Rui Liang Guo-Zhao Meng Huan-Xing Yang Chu-Xiang Zhuang Department of Pathology,Shantou University Medical College,Shantou 515031,Guangdong Province,China Supported by the National Natural Science Foundation of China,No.39670298..Experimental and clinic-opathologic study on the relationship between transcription factor Egr-1 and esophageal carcinoma[J].World Journal of Gastroenterology,2001,7(4):490-495. 被引量：20
9Jing Yi~1 Zhi-Wei Wang~1 Hui Cang~1 Yu-Ying Chen~1 Ren Zhao~2 Bao-Ming Yu~2 Xue-Ming Tang~1 1 Department of Cell Biology,2 Department of Surgery,Ruijin Hospital,Shanghai Second Medical University,Shanghai 200025,China.p16 gene methylation in colorectal cancers associated with Duke's staging[J].World Journal of Gastroenterology,2001,7(5):722-725. 被引量：21
10Chang-Tai Xu~1 Lian-Tian Huang~1 Bo-Rong Pan~2 1 Editorial Department,the Journal of Fourth Military Medical University2 Oncology Center,Xijing Hospital,Fourth Military Medical University,169 Changle Xilu,Xi’an 710032,Shaanxi Province,China.Current gene therapy for stomach carcinoma[J].World Journal of Gastroenterology,2001,7(6):752-759. 被引量：16

引证文献23

1王艳,李岩.大肠癌细胞因子基因治疗的研究现状[J].世界华人消化杂志,2004,12(6):1445-1450. 被引量：3
2吕伟,张超.大肠癌基因治疗的现状和进展[J].中国癌症杂志,2004,14(5):482-485. 被引量：5
3钟选芳,许岸高.大肠癌基因治疗的现状[J].实用医学杂志,2005,21(8):865-867. 被引量：1
4Zong-HaiHuang,Wen-YuYang,QiCheng,Jing-LongYu,ZhouLi,Zong-YanTong,Hui-JuanSong,Xiao-YanChe.Kinase domain insert containing receptor promotor controlled suicide gene system kills human umbilical vein endothelial cells[J].World Journal of Gastroenterology,2005,11(24):3686-3690. 被引量：5
5Wen-Yu Yang,Zong-Hai Huang,Li-Jun Lin,Zhou Li,Jing-Long Yu,Hui-Juan Song,Yong Qian,Xiao-Yan Che.Kinase domain insert containing receptor promoter controlled suicide gene system selectively kills human umbilical vein endothelial cells[J].World Journal of Gastroenterology,2006,12(33):5331-5335. 被引量：5
6刘婷,段晓明,曹建国,贺修胜,童平真,蒋俊豪.HA纳米载体转GM-CSF基因制备自体肿瘤疫苗治疗肝癌的实验研究[J].中国医药导刊,2009,11(2):273-275. 被引量：1
7雷雄,李太原,唐城,戴安邦.结直肠癌C-erbB-2表达与临床病理的关系及意义[J].南昌大学学报（医学版）,2010,50(7):38-41. 被引量：3
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结直肠癌基因治疗研究进展被引量：23

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结直肠癌基因治疗研究进展 被引量：23

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结直肠癌基因治疗研究进展被引量：23