摘要
本文报告用间接免疫荧光试验(IFL)测定200例病毒性肝炎患者血清抗平滑肌自身抗体(SMA)的结果。分析表明:甲型肝炎病毒(HAV)无论是单纯感染或是与乙型肝炎病毒(HBV)合并感染、患者血清SMA的阳性率均较HBV感染时高(P<0.005),而且与HBV复制受抑制相关。HAV感染后可抑制HBV的复制,可能因患者血清中曾存在循环干扰素(IFN),鉴于这种HAV与HBV之间的病毒干扰现象,作者提出,定期多次应用甲肝疫苗或其它药物不断诱生IFN,有可能为乙型肝炎的治疗开辟新的途径。
Smooth muscle autoantibodies(SMA)were examined by indirect immunofluorescence test in 200 patients with viral hepatitis admitted from January 1987 to February 1990. The results showed that there was a higher prevalence of SMA in sera from patients both of simple infection with hepatitis A virus(HAV) and double infection with HAV and hepatitis B virus(HBV) than HBV(P<0.005). On the basis of phenomenon of interference between HAV and HBV, HAV infection can inhibit the replication of HBV because of the presence of circulating interferon(IFN) in patients' sera. The authors suggest that regularly administering hepatitis A vaccine may induce appearenee of IFN in sera, providing a new way to treat hepatitis B.
关键词
肝炎
病毒性
抗体
平滑肌
IFL
smooth muscle autoantibody
viral hepatitis
indirect immunofluorescence test
interferon
