高原地区妊高征患者凝血纤溶系统的变化

CHANGES OF FIBRINOLYSIS COAGULATION SYSTEM IN PATIENTS WITH HYPERTENSION OF PREGNANCY AT HIGHLAND

目的 :探讨高原妊高征患者血液纤溶系统变化 ;方法 :选择高原地区妊高征患者 36例 ,正常妊娠妇女 2 3例 ,正常健康女性 2 0例 ;采集空腹静脉血 ,检测受检者血浆组织纤溶酶原激活剂 (t -PA)、纤溶酶原激活剂抑制物 -1 (PAI -1 )活性及纤维蛋白原(FG)、纤溶降解产物 (FDP)含量 ,并进行分析 ;结果 :高原地区妊高征患者FG和FDP含量及PAI-1活性显著高于正常妊娠组及对照组 ,妊高征患者FG和FDP含量及PAI -1活性的变化与病情程度有关 ,正常妊娠组和妊高征组t-PA活性明显高于正常对照组 ,但在正常妊娠组和妊高征组之间无显著差异 ;结论 :高原地区妊高征患者存在纤溶抑制功能亢进及凝血与纤溶系统的紊乱。

To investigate the changes of the fibrinolysis coagulation system in patients with hypertension of pregnancy at highland.Method:All of subjects were divided into 3 groups.Group 1 was 36 cases with hypertension of pregnancy 23 subjects with normal pregnancy in group 2 and 20 healthy nonpregnancy women in group 3.The level of t-PA,PAI-1,FG and FDP in blood were measured in all group.Results:The level of FG and FDP and activity of PAI-1 were higher in sgroup 1(light,moderote and severe cases) than those in group 2 and 3.The activivty of t-PA was higher in group-1 and 2 than that in group 3,but no significant difference was between group 1and group 2.Conclusion:There is a disturbance of fibrinolysis coagulation system in patients with hypertension of pregnancy at high altitude.