骨化三醇与阿仑膦酸钠治疗骨质疏松症初步观察

Observation of 40 cases of senile osteoporosis treated with calcitriol and alendronate

目的 观察骨化三醇及骨化三醇联合阿仑膦酸钠治疗老年性骨质疏松症 (OP)的疗效及安全性。 方法 将 40例患者随机分成骨化三醇组 ( 19例 )、骨化三醇与阿仑膦酸钠联合治疗组 ( 2 1例 ) ,分别测定治疗前后腰椎及髋部骨密度并观察其疼痛等症状。 结果 联合治疗组L1～ 4 及髋部骨密度均有升高 ,其中L2～ 4 骨密度升高 14 1% (P <0 0 5 ) ;骨化三醇组L1～ 4 ,其中L2～ 4 骨密度升高 7 3 % (P <0 0 5 ) ,髋部无明显升高。 结论 骨化三醇及阿仑膦酸钠联合骨化三醇对骨密度均有明显上升作用 ,联合治疗好于单用骨化三醇。

Objective To observe the efficacy and safety of calcitriol and alendronate on senile osteoporosis(OP). Methods 40 cases of OP were divided into two groups,i.e.calcitriol group(19 cases)and calcitriol plus alendronate group(21 cases).The bone mineral density(BMD)and symptoms were detected before and after treatment. Results In both groups,BMD L 1～4 increased significantly( P <0 05).BMD L 2～4 was increased 7 3% in calcitriol group and 14 1% in calcitriol plus alendronate group. Conclusions Both calcitriol and calcitriol plus alendronate are effective for senile osteoporosis.The effect of calcitriol plus alendronate is superior to calcitriol alone.