脂蛋白(a)与2型糖尿病并发症的关系

Lipoprotein(a)and the type 2 diabetes

目的 探讨血清脂蛋白浓度与 2型糖尿病及并发症的关系。 方法 对 5 2例糖尿病患者及 47例正常对照组的血清脂蛋白 (a) [Lp(a) ]及其他血脂进行分析 ,并比较了糖尿病并发症患者的Lp(a)检测结果。 结果 老年糖尿病患者血清Lp(a) ( 3 12 13± 12 7 3 2 )mg·L-1显著高于对照组 ( 182 0 0± 10 8 0 0 )mg·L-1(P <0 0 5 ) ,甘油三酯 (TG) ( 3 65± 1 93 )mmol·L-1显著高于对照组 ( 1 5 4± 0 87)mmol·L-1(P <0 0 1) ,而血清高密度脂蛋白 (HDL C)、载脂蛋白AI(ApoAI)含量分别低于对照组 (P <0 0 5 )。糖尿病组并发高血压、大血管病变及微血管病变的患者血清Lp(a)浓度明显高于无并发症者 (P <0 0 5 ) ,差异有显著性意义。 结论 血清Lp(a)浓度的升高可能是糖尿病患者心脑血管并发症易发的独立危险因素。

Objective To explore the relationship between the concentratiion of serum lipoprotein(a)[Lp(a)]and complications in patients with the type 2 diabetes mellitus. Methods Lp(a) and other serum lipoproteins were detected in 52 diabetic patients and 47 normal controls. Results The elderly diabetic had higher levels of Lp(a) and triglyceride(TG)than the control gramp and had lower levels of high density lipoprotein choleserol(HDL C)and apolipoprotein AI (apoAI)( P <0 05).In diabetic group,patients with hypertension,macro and micro angiopathy had higher levels of Lp(a)than those without these complications. Conclusions A rise of Lp(a) is an independent and risk factor for diabetic complications.