摘要
目的 :观察海藻消瘿颗粒对小鼠甲状腺吸 1 2 5 I率及尿中 1 2 5 I排出量的影响。方法 :给药组动物分别灌服海藻消瘿颗粒 ( 1.0 14,3.0 42 ,5 .0 7g·kg-1·d-1) ,碘化钾组动物灌服碘化钾 0 .0 0 6 g·kg-1·d-1,连续 10d。末次给药后 1h给小鼠按 10g体重腹腔注射 1 2 5 I 0 .314uci后 ,分别置代谢笼 ,收集 2 4h尿液 ,供尿 1 2 5 I排出量试验用。随后分别于 2 ,6 ,2 4,48h处死动物 ,剥离 ,摘出整个甲状腺 ,放免法测甲状腺吸 1 2 5 I率 ,观察药物的作用。结果 :海藻消瘿颗粒可使甲状腺吸 1 2 5 I率降低 ,同时吸 1 2 5 I率高峰推迟。结论 :海藻消瘿颗粒具有一定的抑制甲状腺功能作用 。
Objective:To study the effect of Haizaoxiaoying granule on the absorption rate of JI125,D,Z by thyroid in mice.Methods:Mice were divided to feed with Haizaoxiaoying granule(1.014,3.042, 5.07 g·kg -1 ·d -1 ) or KI(0.006g·kg -1 ) for 10d.One hour after the last dose,0.314uci/10g body weight of JI125,D,Z was given to each mouse by abdominal injection and urine was collected for determination of JI125,D,Z eliminated.The mice were killed respectively at 2,6,24 and 48h after injection and thyroids were collected and the absorption rate of JI125,D,Z by thyroid was determined by RIA.Results:Haizaoxiaoying granule can reduce the absorption rate of JI125,D,Z by thyroid and delay the peak of absorption.Conclusion:Haizaoxiaoying granule possesses inhibitory effect on thyroid function in some extent. [
出处
《中国新药杂志》
CAS
CSCD
北大核心
2001年第4期274-276,共3页
Chinese Journal of New Drugs
关键词
海藻消瘿颗粒
甲状腺吸碘125
尿碘125排出量
Haizaoxiaoying granule
JI125,D,Z absorbance of thyroid
excretive amount of JI125,D,Z in urine