提高进展期胃癌疗效的研究

A Study of Improving the Treatment for Gastric Cancer

本文介绍了提高进展期胃癌疗效的三项关键性技术———个体化的根治术、亚临床转移灶的处理及合理的综合性治疗的研究结果。应用125I_MAb3H11于放射免疫导向手术及Marayama软件预测胃16组区域淋巴结的转移概率 ,以实施个体化的根治手术。应用188Re_MAb3H11作放射免疫导向治疗及腹腔内温热化疗以处理腹腔内的亚临床转移灶。针对较晚期的进展期胃癌则应用术前化疗、免疫化疗以及磁导向的介入性化疗 ,使胃癌降期以作根治性切除术。上述这些技术均有利于改善胃癌的预后 ,取得令人满意的疗效。

The results of three key techniques——individualized radical resection,management of micro_metastasis,and reasonable multimodality therapy for improving the treatment of gastric cancer were reported.125I_MAb 3H11 for radio_immuno_guided surgery (RIGS) and Marayama soft ware for predicting the metastasis of regional lymph node were used for individualized radical resection.188Re_MAb 3H11 for radio_immuno_treatment(RIT) and intra_peritoneal heating chemotherapy (IPHC)were used for the peritoneal micro_metastasis.The neo_adjuvant chemotherapy,immuno_chemotherapy and magnetic guided interventional chemotherapy were used for advanced cases to down_staging for radical resection.The results of these techniques for improving the prognosis of gastric cancer were quite satisfying.