第1批OTC中成药不良反应文献分析

Review of ARDs of Ready-made Chinese Drugs in the First OTC List

目的：探讨ＯＴＣ中成药的不良反应发生情况，指导合理用药。方法：对国内４０年（１９６０年～２０００年）公开报道的１１６例（次）中成药诱发ＡＤＲｓ进行分析。结果：诱发 ＡＤＲｓ的药物涉及 ３４个品种，其中以藿香正气水 １９例（次）为最多，其次是风油精 １６例（次），三七片１３例（次），这３种药引起的ＡＤＲｓ占４１．４％ ，ＡＤＲｓ类型以过敏反应占的比例最大（６７．２％），１１６例中１１５例治愈（９９．１％），１例死亡。结论：ＯＴＣ中成药也存在不良反应，广大消费者应引起注意，同时也应消除恐慌心理，只要用药得当，ＯＴＣ中成药的ＡＤＲｓ发生率很低，且愈后较好。

OBJECTIVE: To review the ARDs of ready-made Chinese drugs ineluded in OTC list .METHODS: 160 cases of ARDs induced by ready-made Chinese drugs, reported in Chinese journals over 40 years( 1960 ?2000), were analysed .RESULTS: 34 kinds of drugs were involved in inducing ARDs, of which, Huoxiang Zhengqi liquid was the most common one(19 cases) ,essense of Fengyou and pseudo梘inseng tablet were the next(16 cases and 13 cases respectively) .The ARDs induced by above梞entioned 3 drugs accounted for 41.4% of total ARDs.Hypersensitive reaction was the most common ARD (67.2%) .115 of 116 cases were cured, one died .CONCLUSION: Ready-made Chinese drugs can induce ARDs, so the consumers should pay attention to it .however, they need not feel frieghtened.so long as the drugs are used rationally, the incidence of ARDs is very low and the prognosis is good.