神经元特异性烯醇酶与急性脑梗死

Neuron-specific enolase and acute cerebral infarction

目的 探讨急性脑梗死患者血清神经元特异性烯醇酶 (NSE)的变化及其临床意义。方法 采集6 9例脑梗死患者起病 3天内的血标本 ,用酶联免疫分析法测定血清 NSE含量 (其中 35例 2周时复测 )。结果脑梗死 3天内血清 NSE明显高于对照组及 2周时 (P<0 .0 0 1) ,血清 NSE含量与梗死灶大小、神经功能缺损程度明显正相关 (P<0 .0 0 1) ,与意识障碍明显负相关 (P<0 .0 0 1) ,临床疗效越差血清 NSE含量越高 (P<0 .0 0 1)。结论 脑梗死早期血清 NSE明显升高 ,血清 NSE含量与临床表现关系密切。

Objective To explore the change and clinical significance of serum neuron specific enolase (NSE) in the patients with acute cerebral infarction.Methods Blood samples(serum NSE levels) of 69 patients with cerebral infarction were determined by ELISA in the first 3 days,and 35 patients of them were determined again 2 weeks the onset.Results NSE serum levels of patients were significantly higher in the first 3 days than in 2 weeks after the onset and the controls( P <0.001),there was a positive correlation between serum NSE levels and the volume of infraction, neurological deficit scores( P <0.001),and it was negative correlation with disorder of consciousness( P <0.001),the higher serum NSE levels indicated the worse clinical curative effect( P <0.001).Conclusion Serum NSE levels were increased in the early stage of cerebral infarction, and there was a close relationship between NSE serum levels and clinical features.