阿苯达唑及其重要中间体4-丙硫基邻苯二胺的合成——兼评芳香硝基物的选择性还原

SYNTHESIS OF ALBENDAZOLE AND ITS INTERMIDIATE 4-PROPYLTHIO-PHENYLENEDIAMINE——WITH A BRIEF COMMENT ON THE SELECTIVE REDUCTION OF NITROARENES

在对阿苯达唑的合成路线简介的基础上 ,对由 2 硝基 4 丙硫基苯胺制 4 丙硫基邻苯二胺过程中硝基转化为氨基的方法作了简要评述。针对现有工艺的缺点 ,提出了芳香硝基物选择还原的环境友好生产工艺新思路。

A brief introduction was made on the synthesis of albendazole. The ways of transforming nitroarenes to corresponding amine compounds were discussed. Aimed at the pollution problem presently, a new idea of environmental friendly process for the selective reduction of nitroarenes was proposed.