“乳宁Ⅱ号”抑制Ca761小鼠乳腺癌生长转移的实验研究

Experimental Study on the Growth and Metastasis of Mammary Cancer of Ca761 Mice Inhibited by "Ru-Ning Ⅱ

目的 :探索“乳宁Ⅱ号”抑制乳腺癌生长转移的机制。方法 :检测经“乳宁Ⅱ号”等不同方法处理的小鼠乳腺癌肺转移模型的瘤重 ,肺转移发生率及IL -2和TNF的含量 ,并进行组间比较。结果 :Z组与CTX组、Z +CTX组瘤重、肺转移率均低于NS组 (P <0 .0 5 ) ,TNF -α平均值均显著低于NS组 (P <0 .0 5 ) ;Z组IL -2的平均值高于NS组(P <0 .0 5 ) ,而CTX组的平均值低于NS组 (P <0 .0 5 )、Z组与Z +CTX组高于CTX组 (P <0 .0 1)。结论 :“乳宁Ⅱ号”可抑制Ca76 1小鼠乳腺癌生长及肺转移 ,其机制与其抑制TNF分泌及促进IL

Objective: Approach on the mechanism of 'Ru-Ning Ⅱ'used in inhibiting the growth and metastasis of mammary cancer. Methods:Detect the weight of tumor、the incidence rate of lungs metastasis and the content of IL-2 and TNF through lungs metastasis model mammary cancer of mice treated by different method including 'Ru-Ning Ⅱ'et al. Results are compared.Results:The Z group、the CTX group and the Z+CTX group are higher than NS group in the average value of the weight of tumor and the rate of lungs metastasis(P<0.05).They are obviously lower than NS group in TNF-α(P<0.05);About IL-2,the average value of Z group is higher than NS group.The average value of CTX group is lower than NS group.Z group and Z+CTX group are higher than CTX group(P<0.01).Conclusion:The growth metastasis of mammary cancer of Ca761 mice can be inhibited by 'Ru-Ning Ⅱ'.Its mechanism concerns the inhibition of TNF secretion and the promotion of IL-2 secretion.