TNF-α在子宫腺肌病中的表达及其临床意义

THE EXPRESSION AND CLINICAL SIGNIFICANCE OF TNF-α IN ADENOMYOSIS

目的 :检测肿瘤坏死因子α(TNF α)在子宫腺肌病中的免疫组化定位和表达 ,探讨TNF α在子宫腺肌病发生中的临床意义。方法 :采用SABC免疫组化技术观察子宫腺肌病 (33例 )标本中TNF α的组织定位和表达 ,并按照其染色强度进行统计学分析。结果 :子宫腺肌病中存在TNF α的表达 ;TNF α在原位子宫内膜中的表达强度 ,分泌期高于增生期 ,并且呈周期性变化 ;TNF α在异位子宫内膜中的表达强度分别高于原位子宫内膜和正常子宫内膜 ,但是异位子宫内膜和子宫肌层中表达无周期性变化。结论 :TNF α在异位子宫内膜中的高表达提示子宫腺肌病的发生发展受卵巢激素和多种细胞因子的调节。

Objective:To examine the immunohistological localization and the expression of TNF α in adenomyosis,and explore the clinical significance of its expression on the pathogenesis of adenomyosis.Methods:SABC immunohistological technique was used to examine the histological localization and expression of TNF α on 33 adenomyosis specimens,and to compare the statistical difference of its expressive intensity according to the staining color of stained cells.Results:The expression of TNF α was founded in adenomyosis.TNF α expressive intensity of eutopic endometrium in the secretory phase was higher than that of proliferative phase,which showed a periodical change in the adenomyosis.TNF α expressive intensity of ectopic endometrium was higher than that of eutopic endometrium and normal endometrium.However,the expression of TNF α of both ectopic endometrium and the myometrium of the adenomyosis did not show significant cycle variation.Conclusion:It is suggested that the expressions of TNF α in adenomyosis is regulated by sex hormones of ovaries and a few of cytokines.The high expression of TNF α of the ectopic endometrium in the adenomyosis may play an important role in the pathogenesis of the adenomyosis.