肝硬化患者血浆C型利钠多肽测定的临床意义

The Clinical Significance of Determination of Plasma C-type Natriuretic Peptide Levels in Patients with Liver Cirrhosis

目的 :为探讨C -型利钠多肽在肝硬化发病机理中的作用。方法 :用放免法测定了 30例正常人 ,40例血吸虫性肝硬化患者 ,2 5例肝炎后肝硬化患者血浆中C -型利钠多肽的含量。结果 :血吸虫性肝硬化组血浆中CNP含量明显高于正常人组 ,肝炎后肝硬化组血浆CNP含量较正常人组明显升高并明显高于血吸虫性肝硬化组。结论 :CNP可能参与了肝硬化的病理生理过程 ,血浆中的含量检测可作为诊断肝硬化的一项参考指标。

Objective To investigate the relationship between plasma C-type natriuretic peptide (CNP) levels and liver cirrhosis. Methods CNP levels were measured in 30 normal subjects, 25 cases of posthepatitic cirrhosis (PC) and 40 cases of schistosomal cirrhosis (SC) by radioimmunoassay. Results ①The plasma CNP levels in patients with SC were increased significantly as compared with those in the nornal subjects ( P <0.01). ②The plasma CNP in patients with PC were increased markedly as compared with those not only in the controls ( P <0.01) but also the SC patients ( P <0.01). Conclusion CNP might play a certain role in the pathogensesis of liver cirrhosis (LC) and plasma CNP levels might be used as a diagnostic parameter.