支气管动脉灌注化疗加放疗治疗中晚期肺癌45例疗效分析

Analysis of the Curative Effect of Bronchial Artery Infusion in Combination with Radiotherapy on 45 Cases with Midterm-advanced Lung Cancer

目的 报道中、晚期肺癌经介入化疗加放疗的疗效。材料与方法 从 1997年 7月至 1999年 7月间采用经支气管动脉灌注化疗 2次 ,第 2次动脉灌注化疗后 1周加医用电子直线加速器外照射放疗 ,治疗不能手术切除的ⅢB+Ⅳ期非小细胞肺癌 45例 ,放疗剂量DT5 5～ 6 8Gy。结果 近期疗效 :CR率 2 2 2 %、PR率 6 2 2 %、显效率 (CR +PR) 84 4% ,有效缓解率 95 6 %。随访至 2 0 0 0年 7月 ,全组病例 0 5、1和 2年生存率分别为 93 3% (42例 )、6 8 8% (31例 )和 2 2 2 % (10例 )。结论 中晚期肺癌介入化疗加放疗的综合治疗可提高疗效和生存期。

Objective To report the effect of bronchial artery infusion in combination with radiotherapy on treating the patients with midterm advanced lung cancer.Materials and methods From July 1997 to July 1999,forty five patients with stage Ⅲ B+Ⅳ non small cell lung cancer which couldn’t be treated surgically received bronchial artery infusion plus radiotherapy with medical linear accelerator.A week after the second interventio nal chemotherapy into the bronchial arteries,they received tumor doses of 55～68 Gy/28～34fx in 45(37～49) days at 2.0 Gy per fraction.Results Complete remission rate (CR) was 22.2%、partial remission (PR)62.2%、significant remission rate (CR+PR) 84.4% and effective remission rate 95.6%.By July 2000 of the follow up study,the overall 0.5、1 and 2 year survival rate was 93.3%(42/45)、68.8%(31/45) and 22.2%(10/45) respectively.Conclusions Bronchial artery infusion in combination with radiotherapy can improve the effect and raise the survival rate of patients with midterm advanced lung cancer.