Bcl-2和EB病毒与B细胞淋巴瘤关系的研究进展

Advance in the Study of the Relationship between Bcl-2,EBV,EBV-encoded LMP-1 and B cell lymphomas

Bcl 2蛋白能抑制细胞调亡 ,与肿瘤的发生、转化及转移有关。 50 %～ 80 %的滤泡性淋巴瘤 ,10 %～ 2 5%的弥漫性大细胞性B细胞淋巴瘤中有Bcl 2蛋白的表达。EB病毒 (EBV)与免疫缺陷相关性BCL密切相关 ,而与非免疫缺陷相关性BCL的相关性较小。EBV在体外可以诱导B淋巴细胞表达Bcl 2蛋白。该病毒可能通过LMP 1诱导Bcl

Bcl 2 protein can protect cells from apoptosis and has relations with the development、transformation and metastasis of tumor.Bcl 2 protein was expressed in 50%-80% of follicular lymphomas、10%-25% of diffuse large B cell lymphomas.Epstein Barr virus(EBV) has a strong association with B cell lymphomas(BCLs)in immunodeficient patients,but the relationship between EBV and BCLs in immunocompetent patients is rarely eminent.Induction of Bcl 2 expression by EBV in B cells has been reported in vitro.EBV may play a role in the pathogenesis of BCLs in immunodeficient patients by inducing Bcl 2 protein expression through LMP 1.