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肾上腺素诱导培养新生大鼠心肌细胞肥大的实验研究 被引量：1

EXPERIMENTAL STUDY OF CARDIOCYTE HYPERTROPHY INDUCED BY ADRENALINE IN CULTURED NEONATAL RAT MYOCARDIAL CELLS
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摘要 目的 :探讨肾上腺素诱导心肌细胞肥大的作用。方法 :在培养新生大鼠心肌细胞上 ,通过测量心肌细胞表面积和[3H] -Leu的掺入量来判断心肌细胞肥大。结果 :肾上腺素能明显增加心肌细胞表面积和[3H] -Leu的掺入量 ,并呈量效关系。结论 Objective: The present study was to investigate the effects of cardiocyte hypertrophy induced by adrenaline. Method: The cell surface area and -Leucine incorporation were measured to judge the hypertrophy of cardiac cells in cultured neonatal rat myocardial cells. Results: Adrenaline could significantly increase the surface areas of the cells and promote -Leucine incorporation with dose-dependent. Conclusion: The results suggest that adrenaline can induce cardiocyte hypertrophy in cultured neonatal rat myocardial cells.
作者 谢协驹 符史干 吉丽敏
机构地区 海南医学院病理生理学教研室
出处 《海南医学院学报》 CAS 2001年第1期1-3,共3页 Journal of Hainan Medical University
关键词 肾上腺素 诱导 心肌肥大 新生大鼠 心肌细胞 细胞培养 Adrenaline cell size hypertrophy cardiac muscle
分类号 R542.2 [医药卫生—心血管疾病]
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参考文献7

  • 1Bogoyevitch MA., Andersson MB., Gillespie Brown J., et al. Adrenergic receptor stimulation of the mitogen - activated protein kinase cascade and cardiac hypertrophy . Biochem J,1996,314(1): 115 ～ 121
  • 2龚素珍,刘培庆,鲁伟,符史干,潘敬运.新生大鼠心室成纤维细胞条件培养液的促心肌细胞肥大作用[J].生理学报,2000,52(1):34-38. 被引量：12
  • 3陈国伟 伍贵富 杨惠玲 潘景轩 吴伟康 主编.心力衰竭[A].杨惠玲,潘景轩,吴伟康,主编.高级病理生理学[C].北京:科学出版社,1998.244-264.
  • 4Zhong H ., Minneman KP. Alpha1 - adrenoceptor subtypes. Eur J Pharmacol, 1999,375 ( 1 - 3): 261 - 276
  • 5Autelitano DJ., Woodcock EA. Selective activation of alpha1A - adrenergic receptors in neonatal cardiac myocytes is sufficient to cause hypertrophy and differential regulation of alpha1 - adrenergic receptor subtype mRNAs. J Mol Cell Cardiol, 1998,30(8): 1515 ～ 1523
  • 6Engelhardt S ., Hein L., Wiesmann F., et al. Progressive hypertrophy and heart failure in beta1- adrenergic receptor transgenic mice. Proc Natl Acad Sci USA,1999, 96(12): 7059 ～ 7064
  • 7Senard JM., Galinier M., Valet P., et al. Beta adrenergic receptors and experimental left ventricular hypertrophy. Arch Mal Coeur Vaiss,1992,85(8) :1107～ 1111

二级参考文献3

  • 1Guo W N，J Mol Cell Cardiol，1998年，30卷，157页
  • 2Yu H，Hypertension，1997年，30卷，1047页
  • 3Long C S，CellReg，1991年，2卷，1081页

共引文献15

同被引文献11

  • 1蒋青松,黄燮南,戴支凯,杨贵忠,周岐新,吴芹,石京山.川芎嗪对PGF_(2α)诱导心肌肥大的抑制作用[J].中药药理与临床,2005,21(2):9-11. 被引量：5
  • 2Kazufumi N, Kazuo F,Hirosuke K, et al. Inhibitory Effects of Antioxidants on Neonatal Rat Cardiac Myocyte Hypertrophy Induced by Tumor Necrosis Factor-or and Angiotensin II. Circulation, 1998,98:794-799.
  • 3Cheng-Ming Cheng, Hong-Jye Hong, Ju-Chi Liu, et al. Crucial Role of ExtraceUular Signal-Regulated Kinase Pathway in Reactive Oxygen Species-Mediated Endothelin-1 Gene Expression Induced by Endothelin-1 in Rat Cardiac Fibroblasts. Mol. Pharmacol,2003,63 : 1002.
  • 4Sadoshima J, lzumo s. Molecular characterization of angiotensin Ⅱ-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype. Circ Res, 1993,73:413- 423.
  • 5Adams JW, Migita DS, Yu MK,et al. Prostaglandin F2 alpha stimulates hypertrophic growth of cultured neonatal rat ventricular myocytes. J Biolchem, 1996,271 ( 2 ) : 1179-1186.
  • 6Harary I, Farley B. In vitro studies Of single isolated beating heart cell. Science, 1960,131 : 1674-1675.
  • 7Higuchi Y, Ostu k, Nishida K, et al. Involvement of reactive oxygen species mediated NF-kappa B activation in TNF-alpha-induced cardiomyocyte hypertrophy J. J Mol Cell Cardio1,2002,34 ( 2 ) :233-240.
  • 8Nakagami H, Takemoto M, Liao JK. NADPH oxidase-derived superoxide anion mediates angiotensin-induced cardiac hypertrophy. J Mol Cell Cardiol,2003,35:851-859.
  • 9Karmasyn M. Synthesis and relevance of cardiac eicosanoids with particular emphasis on ischemia and reperfusion. Can J Physiol Pharmacol, 1989,67 (8) :912-921.
  • 10Masato Katsuyama, ChunYuan Fan, Chihiro Yabc-Nishimura. NADPH Oxidase Is Involved in Prostaglandin F2α-induced Hypertrophy of Vascular Smooth Muscle Cells. Induction of NOX1 by PGF2α. J Biol Chem,2002,277 : 13438-13442.

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海南医学院学报
2001年 第1期

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