血清β_2-微球蛋白测定对婴幼儿重症肺炎肾功能改变的诊断价值

The Validity of Using Serum β_2-Microglobulin Detection to Predict the Renal Function Impaired in the Infants with Severe Pneumonia

目的 :探讨婴幼儿重症肺炎伴发肾功能损害时血清 β2 -微球蛋白 (β2 - MG)与肌酐 (Cr)、尿素氮 (BUN)测定的诊断意义。方法 :观察组为 PICU抢救治疗的 6 8例婴幼儿重症肺炎于入院 2 4h内及病情缓解后分别测定血清β2 - MG及BUN、Cr,设 2 2例正常儿童为对照组。结果 :血清β2 - MG第 1次测定与对照组比较有极显著性差异 (t=13.2 5 6 ,P<0 .0 0 1) ,第 2次测定无显著性差异 (t=0 .6 96 3,P>0 .0 5 )。 2次 BUN、Cr测定均在正常范围 ,与对照组比较无显著性差异。结论 :婴幼儿重症肺炎时 ,肾功能损害普遍存在 ,血清β2 - MG测定能早期及时发现肾功能改变。

Objective:To evaluate the significance of determinations of serum β 2 microglobulin(β 2 MG),serum creatinine(Cr) and blood urea nitrogen (BUN) in prediction of renal condition impaired associated with severe pneumonia in the infants.Methods:Sixty eight infants with severe pneumonia admitted into the pediatric intensive care unit(PICU) were selected for the trial group,the serum levels of β 2 MG,BUN and Cr were determined in 24 hours after admission and at the time when the disease was relieved.Other 22 healthy infants served the control group.The results were presented as ±s and the significance of difference was evaluated by t test.Results:The serum β 2 MG concentration of the ill infant measured at 24h after admission was 3.474±0.27mg·L -1 ,significanlly higher than that of the control group (2.387±0.21mg·L -1 ),no significant difference was observed between serum β 2 MG levels of the trial group determined when disease was relieved and that measured in the control infants.All measurements of BUN and Cr were within normal range(2.387±0.27mg·L -1 ) and no significant difference was seen as compared to the control.Conclusions:It is found that renal function impairment is commonly associated with severe pneumonia in infants,and determination of serum β 2 MG can be used to predict renal function conditions.