A型肉毒毒素声带注射治疗内收型痉挛性发声障碍

Adductor Spasmodic Dysphonia Treated by Injecting of Botulinum Toxin A into Vocal Cords

目的 探讨双侧声带注射 A型肉毒毒素治疗内收性痉挛性发声障碍疗效。方法 在直接喉镜下于双侧声带近外侧甲杓肌处注射 A型肉毒毒素各 2 .5 U治疗内收性痉挛性发声障碍 11例。结果 均在注射后 2 4h即显效 ,发声改善平均持续时间 16 .2 wk,不良反应有暂时过度呼吸音 11例、饮水呛咳 5例 ,吞咽困难 3例 ,未发现 A型肉毒毒素全身毒副作用。结论 直接喉镜下 A型肉毒毒素双侧声带注射是治疗内收性痉挛性发声障碍有效、安全。

Objective To investigate the effect of botulinum toxin A(BTA) injected into vocal cords for the treatment of adductor spasmodic dysphonia (SD) by direct lanyngoscopy.Methods 11 patients with adductor SD were treated by injection on both vocal cords each with 2.5U of BTA by direct laryngoscopy.Results All patient's phonation improved within the first 24 hours,with sustained improvement from 12 to 21 weeks with an average of 16.2 weeks.The local side effect included breathy voice in all cases and mild choking sensation when drinking fluids in 5 cases,dysphagia in 3 cases.No systemic adverse reactions were noted.Conclusion The injection of BTA on both vocal cords by direct laryngoscopy is an effective,safe and simple method for the treatment of adductor SD.