尿游离T_3固相放射免疫测定结果分析

An analysis of the urinary free T_3 Ievels with solid—phase radioimmunoassay

应用固相FT_3放射免疫药盒测定25例甲亢,14例甲低和29例对照组的血清FT_3和尿FT_3;对照组24h尿FT_3含量为3.53±1.61pmol/24h;甲亢组为35.41±24.46pmol/24h;甲低组为1.04±0.80pmol/24h。与对照组比较有显著性差异。甲亢组与甲低组24h尿FT_3含量能反映血中FT_3水平。提示诊断甲亢和甲低及研究甲状腺素代谢时,测定尿FT_3有重要意义。

The urivarv FT_3 of 24h and the concentrations of serum FT_3,T_4 and T_3 in unextacted sample were measured with solid--phase radioimmunoassay in 25 patients with hyperthyroidism, 14 patientswith hypothyroidism and 29 individuals of controls,The unextracted urinary FT_3 levels were35. 41±24. 46pmol/24hr. in hyperthyroid patients, 1. 04±0. 80pmol/24hr. in hypothyroid patientsand 3. 53±1. 61pmol/24hr. in the controls. The difference was statistically signficant betweenhyperthyroidism and hypothyroidism and the controls. The results showed that the urinary FT_3 of 24hr.could reflects the serum FT_3 in both hyperthiroid patients and hypothyroid patients. The measurementof urinary PT_3 is a fine indicator of thyroid function in the diagnosis of thyroid disease and the researchof the metabolism of thyroid hormone. That the correlation betwwen urinaty FT_3 and serum FT_3 cannot be obtained in the controls is perhaps because the effects on the FT_3 excretion in normal range ofserum FT_3 level relatively increase.