食管癌高发区青少年与中老年人食管粘膜活检组织病理学比较研究

Comparative study on the esophageal mucosa histopathology of the young and the middle and old aged persons in the high—risk area of esophageal cancer

本文首次报告食管癌高发区420名15～25岁青少年食管粘膜活检组织病理学普查结果,并与同一地区321名中老年人食管粘膜活检组织病理学结果进行比较。结果表明青少年已出现食管粘膜乳头升高,中性粒细胞浸润,不全角化,基底细胞增生及间变等慢性食管炎的形态学改变。中性粒细胞浸润,不全角化,基底细胞增生及间变随年龄增长而升高,男性略大于女性。这一研究有助于加深对食管癌前病变的发生和发展的认识,寻找一些与食管癌发生密切相关的病理学危险指标,并为食管癌的Ⅱ级预防提供可靠的依据。

This paper is the first report about the results of the general pathological investigation of theesophageal mucosa biopsy of 420 young persons from 15 to 25 in a high--risk area of esophageal can-cer. The results have been compared with those obtained from 321 middle and old aged persons in thesame area. The results indicate that papillae upgrowth, neutrophilic granuloce infitration, parakeratosis.basal cell hyperplasia and dysplasia were not uncommon in the young people and that the incidence ofneutrophilic granulocye infiltration, parakeratosis,basal cell hyperplasia and dyaplasia increased withthe increase of the age and is a little higher in the male than in the female. This study helps to recognizethe genesis and development of the precanerous lesions of esophageal carcinoma,to find the criteria ofpathological risk clasely related to the occurrence of esophageal carcinoma,and to provide reliable basisfor the second class prevention of esophageal cancer.