心复康Ⅰ号的药效学研究——小鼠急性毒性及耐缺氧实验

The Pharmacodynamic study of XIN FU-KANG NO.I ——The tests of acute toxicity and anoxic tolerance

用心复康Ⅰ号作了小鼠急性毒性及耐缺氧实验。实验证明心复康Ⅰ号对常压耐缺氧、异丙肾上腺素引起的心肌耗氧量增加,亚硝酸钠、氰化钾中毒及结扎双侧颈总动脉的脑缺血缺氧均有明显地保护作用,把原中药复方煎剂经剂型改造成口服液其药理活性不变。

The purpose of the experiments was to prove the acute toxicity and the effect of anoxic tolerance of XTN FU--KANG No. Ⅰ. The results of the expeiments indicated that XTN FU--KANG No.Ⅰ hadobvious protective effect on the anoxic tolerance under normal atmosphere, the increase of oxygen con-sumption in the heart muscle induced by isoprenaline,the intoxication due to sodium nitrite or kaliumcyanide,and the brain ischemia and anoxia caused by the ligated bilateral common caroted arteries. Thepharmacological active part in the oral solution was not different from that of the compound prepera-tion of the traditional Chinese medicine.