山楂提取物对体内合成甲基苄基亚硝胺及其诱癌的阻断作用

The blocking effect of hawthorn extract on the internal synthesis of methylbenzyl-nitrosamine and its carcinogenesis

用Wistar大鼠130只及昆明小鼠100只分为4组。1,2,3组动物均灌喂6.4g/L亚硝酸钠溶液和10g/L甲基苄胺溶液。第2,3组动物在灌喂上述液体的同时,分别再灌喂1500g/L山楂提取液,1.35g/L维生素C溶液。第4组动物灌喂蒸馏水作为对照。大鼠在灌喂40次,小鼠为16次后处死。实验表明:灌喂亚硝酸钠溶液和甲基苄胺溶液的小鼠及大鼠,其食管及前胃上皮均有不同程度的增生性病变,其中5只大鼠诱发了前胃乳头状瘤。若灌喂亚硝酸钠溶液和甲基苄胺溶液的小鼠及大鼠,同时再灌喂山楂提取液时,食管或前胃上皮均无明显形态学变化。提示山楂提取液对体内合成甲基苄基亚硝胺诱癌有显著的阻断作用。

In this experiment, 130 wistar rats and 100 kunming mice were divided into one control groupand 3 experimental groups. All the animals in the exprimental groups were given 6. 4g/L sodium nitritesolution and 10g/L N-methylbenzylamine solution intragastrically, 0. 5ml of each soution twice aweek for the rats and 0. 25ml once a week for the mice,and at the same time, 1500g/L hawthorn ex-tract were poured into the stomachs of the rats and mice in Group 2, 1 ml for the rats and 0. 5ml for themice; in Group 3, 1. 35g/L vitamine C solution given in the same dose; in the control group,distilledwater was used in the same way, 2ml twicc a week for the rats and 1ml once a week for mice. The ani-mals were killed after being poured 40 times for the rats and 16 times for the mice. The expermentalresults indicated that hawthorn extract had remarkable inhibition on the synthesis and carcinogenesis ofmethyl--benzyl--nitrosamine in vivo.