食管癌高发区青少年食管炎发病率和发病因素研究

Study on the Prevalence and Etiology of Chronic Esophagitis Among Young Persons in High—Risk Areas of Esophageal Cancer

为了研究食管炎与食管癌的关系及食管炎的发病因素,对食管癌高发区15～25岁的222个食管癌家族青少年和318个非癌家族青少年进行了普查。病理诊断食管炎在食管癌家族和非癌家族青少年中分别为50.2％和34.4％(P<0.01),表明在食管癌高发区食管炎与食管癌的发病有关。食管炎发病因素的病例对照研究结果表明,热饮、经常食用棉籽油、吸烟、摄入新鲜蔬菜水果和动物蛋白不足是主要的致病因素。

Two hundred and twenty—two young people between 15 and 25 years of age from households of esophageal cancer and 318 from households without esophageal cancer were selected, and participated in the field study conducted in Huixian county, a high—risk area of esophageal cancer in China. There is marked difference between the prevalence of esophagitis diagnosed histologically among those subjects from case households and control households: 50.2％ versus 34. 4%, indicating a relationstip between chronic esophagitis and cancer in this area. In the case—control analysis of risk factors for chronic esophagitis, it was observed that the drinking of beverages at burning hot temperatures, cigarette smoking, longterm use of cottonseed oil and low intake of green vegetables, fruit and animal protein were found to be relevant for chronic esophagitis.