肺癌病人血清铜、锌水平的研究

A Study on the Serum Copper/Zinc Level in Patients with Lung Cancer

本研究应用原子吸收分光光度法，检测１８６例肺癌病人血清铜、锌水平，并以１６０例正常人和６４例良性胸部疾患病人作对照。结果显示：肺癌病人血清铜水平明显高于良性胸部疾患病人和正常人。血清锌水平明显低于良性胸部疾患病人和正常人。铜、锌水平的改变与肺癌的病期有明显的关系（Ｐ＜０．０１），而与组织学类型无关。本研究结果表明：检测肺癌病人血清铜、锌水平可用于肺癌的辅助诊断和判别肺癌的病期。

In this study,serum Copper/zinc level was detected by atomic absorption spectrophotometry in 186 lung cancer,to comparing these tests,150 normal adults and 64 benign thoracic lesions were taken as control,The results showed that:(1)the serum copper level in patients with lung cancer was significantly higher than that in benign thoracic lesions and normal adults(P<0.01).(2)the serum zinc level in lung cancer was significantly lower than that in benign thoracic lesions and normal adults(P<0.01).(3) the change of Serum copper/zine level in lung cancer patients is closely related to the stages of cancer,but not to the histological classification.These results suggest that determination of serum copper/zine level may be used as a diagnostic test in lung cancer patients,and it might be also a useful tool for distinguishing stages of the cancer.